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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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10.1016/j.bbamcr.2003.10.006 Biochim

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Independent replication by unaffiliated laboratories is limited

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