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Leveraging AlphaFold, the structure of Fks1, the -1,3-glucan synthase targeted by echinocandins, was resolved, revealing resistance-associated mutations, catalytic mechanisms, and the GTP-dependent conformational activation by Rho1 (Hu et al., 2023

Its deficiency can lead to a condition called anemia, which often manifests as fatigue

a preclinical study

Plant Cell Environ

You are encouraged to report negative side effects of prescription drugs to the FDA