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tirzepatide's dedicated SURPASS-CVOT cardiovascular outcomes trial is ongoing

These patients may require combination therapy with basal insulin or other agents targeting different pathophysiological mechanisms

Zambrano, M

Nausea, diarrhea, and decreased appetite occur most frequently but typically improve within the first few weeks

The most frequently reported adverse reactions (1% or more and twice rate of placebo) were ECG voltage criteria for ventricular hypertrophy, tic, vomiting, psychomotor hyperactivity, insomnia, decreased appetite and rash [2 instances for each adverse reaction, i.e., 2/218 (1%)]

If you are struggling to hit protein at all on a given day, the bowl is not the only lever