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Since GSH is not carried inside the cell, exogenously administered GSH is most likely to act by increasing plasma GSH levels reducing luminal oxidative stress and increasing NO bioavailability in patients with endothelial dysfunction (220)

Advances in clinical treatment of metabolic disorders N-acetylcysteine (NAC) is a thiol-containing antioxidant and a precursor of GSH, exerting an indirect antioxidant effect by inducing GSH synthesis

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