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Canine progressive retinal atrophies (PRA) are genetically heterogeneous diseases caused by several mutations and affect more than 100 dog breeds
The myostatin protein has been shown to have effect on muscle growth
severe self-mutilations of the feet including claw loss
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Dog is homozygous for normal allele
D-Lokus (d2) Startseite Canine progressive retinal atrophies (PRA)D Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red yellow pheomelanin, though in lesser extent.
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