Hypomyelinisierung / Shaking Puppy Syndrome (SPS) Hunde resulting in the deterioration of

resulting in the deterioration of the inner ear hair bundles and progressive hearing loss

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Only a few days prior the death they show some of various clinical signs such as vomiting

der ein wichtiger Vermittler in der Signaltransduktion in Netzhautrezeptoren ist

I-Locus causes so called »extreme dilution« of the pheomelanin

Hypomyelinisierung / Shaking Puppy Syndrome (SPS) Hunde resulting in the deterioration ofShaking puppy syndrome (SPS) or hypomyelination syndrome (HS) is a disease characterized by an abnormally low amount of myelination or its absence in the axons of the central nervous system (CNS). SPS has been described in people and in dogs including Dalmatian, Bernese Mountain dog, Chow Chow and Weimaraner breeds. The cause of SPS is not known in all breeds. A causative mutation in the gene in Weimaraner breeds has been reported. In Weimaraner